Protocol-directed sedation versus non-protocol-directed sedation to reduce duration of mechanical ventilation in mechanically ventilated intensive care patients

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Protocol-directed sedation versus non-protocol-directed sedation to reduce duration of mechanical ventilation in mechanically ventilated intensive care patients.

BACKGROUND The sedation needs of critically ill patients have been recognized as a core component of critical care and meeting these is vital to assist recovery and ensure humane treatment. There is growing evidence to suggest that sedation requirements are not always optimally managed. Sub-optimal sedation incorporates both under- and over-sedation and has been linked to both short-term (e.g. ...

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Early goal-directed sedation versus standard sedation in mechanically ventilated critically ill patients: a pilot study*.

OBJECTIVE To assess the feasibility and safety of delivering early goal-directed sedation compared with standard sedation. DESIGN Pilot prospective, multicenter, randomized, controlled trial. SETTING Six ICUs. PATIENTS Critically ill adults mechanically ventilated for greater than 24 hours. INTERVENTIONS Patients randomized to early goal-directed sedation received a dexmedetomidine-base...

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Alpha-2 agonists for sedation in mechanically ventilated neurocritical care patients: a systematic review protocol

BACKGROUND Sedation is an important consideration in the care of the neurocritically ill patient. It provides anxiety and relief, facilitates procedures and nursing tasks, and minimizes intolerance of mechanical ventilation. Alpha-2 agonists such as dexmedetomidine and clonidine have been shown to be an effective alternative in the general critical care population by reducing duration of mechan...

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Management of sedation in mechanically ventilated patients.

PURPOSE OF REVIEW There are many new and exciting studies in the sedation literature. Recent studies of new scoring systems to monitor sedation, new medications, and new insights into post-intensive care unit (ICU) sequelae have brought about interesting ideas for achieving an adequate level of sedation of our patients while minimizing complications. RECENT FINDINGS The recent literature focu...

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Impact of a clinical pharmacist-enforced intensive care unit sedation protocol on duration of mechanical ventilation and hospital stay.

OBJECTIVE While the use of a protocol to guide sedation and analgesia therapy in the intensive care unit has been shown to improve patient outcomes, compliance is often poor. We hypothesized that a formal, consistent intervention by pharmacists to promote adherence to our institution's sedation guidelines would improve clinical outcomes. The purpose of this study was to document the impact of d...

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ژورنال

عنوان ژورنال: Cochrane Database of Systematic Reviews

سال: 2015

ISSN: 1465-1858

DOI: 10.1002/14651858.cd009771.pub2